Abstract
Objective To explore the effect and safety of mild hypothermia therapy combined with monosialotetrahexosylganglioside (GM1) on neural function recovery of neonatal asphyxia complicated by hypoxic ischemic encephalopathy (HIE). Methods The clinical data of 90 neonates with HIE were retrospectively analyzed. According to the treatment methods, the neonates were divided into a routine group, a mild hypothermia group, and a combination group, with 30 cases in each group. The differences in neural function recovery, biochemical indexes, clinical signs recovery, efficacy, and complications were observed in the three groups after treatment. Results After treatment, the score of neonatal behavioral neurological assessment (NBNA) and level of superoxide dismutase (SOD) in the combination group were higher than those of the other two groups (P < 0.05). The levels of neuron-specific enolase (NSE), S-100β protein, and plasma neuropeptide Y (NPY) in the combination group were lower than those in the other two groups, and the recovery time of consciousness, muscle tension, and reflex was shorter (P < 0.05). The combination group showed higher total effective rate and lower incidence of complications as compared with the other two groups (P < 0.05). Conclusion Mild hypothermia therapy combined with GM1 for the treatment of neonatal asphyxia complicated by HIE can promote the recovery of neural function and reduce the incidence of complications in neonates.
Highlights
Neonatal hypoxic ischemic encephalopathy (HIE) is a common perinatal disease in clinic, which is mainly caused by perinatal asphyxia
Mild hypothermia therapy has been proven to be an effective treatment for HIE
Mild hypothermia therapy can effectively improve the neurological function of children with HIE and inhibit the inflammatory response [20]
Summary
Neonatal hypoxic ischemic encephalopathy (HIE) is a common perinatal disease in clinic, which is mainly caused by perinatal asphyxia. Mild hypothermia therapy has been shown to be effective in treating HIE and reducing the mortality of affected neonates [6, 7]. This treatment has certain requirements for the onset time window of children and may cause a series of adverse reactions such as fat necrosis and arrhythmia in neonates [8]. A study has shown that GM1 used in HIE treatment can improve the short-term clinical efficacy and reduce long-term neurodevelopmental disorders in neonates [12]. GM1 combined with hyperbaric oxygen therapy for HIE can effectively improve the short- and long-term nervous system
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