Abstract
The enteric nervous systems (ENS) in humans contain more neurons than the aggregate of all other peripheral ganglia and are responsible for orchestrating and maintaining all aspects of gastrointestinal (GI) homeostasis. The development of the ENS is a complex process derived from neural crest cells (NCCs) that commences predominantly at the vagal level of the neural tube and ends in the distal hindgut. The traditional model of enteric neural crest cells (ENCCs) migrating in a unidirectional (rostral-to-caudal) fashion within the gut mesenchyme to colonize the entire length of the gut has recently come into question with an alternative trans-mesenteric migratory model. Errors in migrations of ENCCs lead to the development of several congenital and acquired disorders of the digestive tract. Novel stem cell tissue-engineering approaches provide an exciting avenue in future treatments of enteric neuropathies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
