Abstract
Although the memory impairment is a hallmark of Alzheimer’s disease (AD), AD has also been characterized by spatial disorientation, which is present from its early stages. Spatial disorientation in AD manifests itself in getting lost in familiar and unfamiliar places and have been characterized more specifically using spatial navigation tests in both real space and virtual environments as an impairment in multiple spatial abilities, including allocentric and egocentric navigation strategies, visuo-spatial perception, or selection of relevant information for successful navigation. Patients suffering mild cognitive impairment (MCI), who are at a high risk of development of dementia, show impairment in a subset of these abilities, mainly connected with allocentric and egocentric processing. While spatial disorientation in typical AD patients probably reflects neurodegenerative changes in medial and posterior temporal, parietal, and frontal lobes, and retrosplenial cortex, the impairment of spatial navigation in MCI seem to be connected mainly with the medial temporal and also parietal brain changes. In this review, we will summarize the signs of brain disease in most MCI and AD patients showing in various tasks of spatial memory and navigation.
Highlights
Spatial disorientation is one of the early manifestations of Alzheimer’s disease (AD), besides the clinically mostly used memory impairment
The research in spatial deficits in this neurodegenerative disease has grown rapidly in last years and decline in spatial navigation abilities may become another diagnostic mark for AD in the near future
This review aims to describe spatial disorientation in AD and mild cognitive impairment (MCI) as a multi-factorial deficit connected with changes in several brain regions
Summary
Neural correlates of spatial navigation changes in mild cognitive impairment and Alzheimer’s disease. The memory impairment is a hallmark of Alzheimer’s disease (AD), AD has been characterized by spatial disorientation, which is present from its early stages. Patients suffering mild cognitive impairment (MCI), who are at a high risk of development of dementia, show impairment in a subset of these abilities, mainly connected with allocentric and egocentric processing. While spatial disorientation in typical AD patients probably reflects neurodegenerative changes in medial and posterior temporal, parietal, and frontal lobes, and retrosplenial cortex, the impairment of spatial navigation in MCI seem to be connected mainly with the medial temporal and parietal brain changes. We will summarize the signs of brain disease in most MCI and AD patients showing in various tasks of spatial memory and navigation
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