Neural correlates of autobiographical memory retrieval: An SDM neuroimaging meta-analysis

Abstract

Autobiographical memory (AM) is a type of episodic memory that involves the recollection and re-experiencing of personal life events. AM retrieval is a complex process requiring the coordination of multiple memory processes across the brain. Important questions remain regarding the degree to which specific brain regions are consistently recruited during AM retrieval and the influence of methodological factors such as type of AM retrieval task and control task. Neuroimaging meta-analyses can summarize the brain regions associated with AM retrieval, addressing these questions by revealing consistent findings across multiple studies. We used a coordinate-based neuroimaging meta-analysis method, seed-based d mapping (SDM), to assess the largest set of neuroimaging studies of AM retrieval to date. An important advantage of SDM over other methods is that it factors in the effect sizes of the activation coordinates from studies, yielding a more representative summary of activations. Studies were selected if they elicited AM retrieval in the scanner, contrasted AM retrieval with a matched control task, and used univariate whole-brain analyses, yielding a set of 50 papers with 963 participants and 891 foci. The findings confirmed the recruitment of many previously identified core AM retrieval regions including the prefrontal cortex (PFC), hippocampus and parahippocampal cortex, retrosplenial cortex and posterior cingulate, and angular gyrus, and revealed additional regions, including bilateral inferior parietal lobule and greater activation extent through the PFC, including lateral PFC activation. Results were robust across different types of AM retrieval tasks (previously rehearsed cues vs. novel cues), and robust across different control tasks (visual/attention vs. semantic retrieval). To maximize the utility of the meta-analysis, all results image files are available online. In summary, the current meta-analysis provides an updated and more representative characterization of the neural correlates of autobiographical memory retrieval and how these neural correlates are affected by important experimental factors.