Neural correlates of auditory sensory memory dynamics in the aging brain

Abstract

The auditory system allows us to monitor background environmental sound patterns and recognize deviations that may indicate opportunities or threats. The mismatch negativity and P3a potentials have generators in the auditory and inferior frontal cortex and index expected sound patterns (standards) and any aberrations (deviants). The mismatch negativity and P3a waveforms show increased positivity for consecutive standards and deviants preceded by more standards. We hypothesized attenuated repetition effects in older participants, potentially because of differences in prefrontal functions. Young (23 ± 5 years) and older (75 ± 5 years) adults were tested in 2 oddball paradigms with pitch or location deviants. Significant repetition effects were observed in the young standard and deviant waveforms at multiple time windows. Except the earliest time window (30–100 ms), repetition effects were absent in the older group. Repetition effects were significant at frontal but not temporal lobe sites and did not differ among pitch and location deviants. However, P3a repetition was evident in both ages. Findings suggest age differences in the dynamic updating of sensory memory for background sound patterns.