Neural Correlates of Abnormal Cortical Gait Control in Parkinson's Disease: A Whole-Gait-Cycle EEG Study.

Abstract

Electroencephalography (EEG) with high time-resolution allows for recording dynamic cortical activity during walking and provides new insight into the underlying pathophysiology of gait impairments in PD. However, traditional gait-phase-specific EEG analysis only measures the brain activities in the isolated gait phase, but neglects the between-gait-phase interactions as well as the whole-gait-cycle characteristics, and therefore is unable to effectively reflect the abnormal cortical gait control. In this study, we introduced three whole-gait-cycle measures of intra-stride EEG activity (i.e., mean desynchronization, amplitude of fluctuations, and coupling to the gait phase), and investigated their abnormalities in PD and relationships with gait impairments, which were further compared with the traditional gait-phase-specific measures. Compared with healthy controls, PD patients showed overwhelming stronger desynchronizations (ERD) across the whole gait cycle in θ, α and low-β bands, implying a cortical compensatory strategy in response to the low efficiency of the motor network. Patients also exhibited weaker intra-stride ERD fluctuations in the central area in α and low-β bands, with reduced amplitude and less coupling to the gait phase, which were correlated with gait impairments in walking speed, gait rhythm and walking stability. However, gait-phase-specific EEG measures did not show any significant correlation with gait impairments in PD. Our results demonstrated the efficiency of whole-gait-cycle EEG measures in characterizing the abnormal cortical gait control, and for the first time, associated gait impairments with weak intra-stride electrocortical fluctuations. The findings may shed light on the development of cortical-targeted interventions for PD.