Abstract
Objective: Misophonia is a newly described condition in which specific ordinary sounds provoke disproportionately strong negative affect. Since evidence for psychobiological dysfunction underlying misophonia is scarce, we tested whether misophonia patients, like many patients with impulse control or obsessive-compulsive spectrum disorders, show impaired ability to inhibit an ongoing motor response.Methods: We collected functional magnetic resonance imaging data during a stop signal task in 22 misophonia patients and 21 matched healthy controls.Results: Compared to controls, patients tended to show longer stop signal delays, which is the time between stimuli signaling response initiation and inhibition. Additionally, patients tended to activate left dorsolateral prefrontal cortex more during responding rather than successful inhibition, as was seen in controls. Furthermore, patients lacked inhibition success-related activity in posterior cingulate cortices and activated the superior medial frontal gyri less during inhibition success compared to failure, a feature correlated with stop signal delays over the sample.Conclusions: Misophonia patients did not show impaired response inhibition. However, they tended to show a response bias on the stop signal task, favoring accuracy over speed. This implies perfectionism and compulsive, rather than impulsive, behavior. Moreover, brain activations were in line with patients, compared to controls, engaging more cognitive control for slowing responses, while employing more attentional resources for successful inhibition.
Highlights
Misophonia is a newly described psychiatric condition in which specific ordinary sounds, such as breathing or lip-smacking, provoke disproportionately strong feelings of irritability, anger, and/or disgust [1,2,3]
Patients and controls did not differ in age, sex, education level, or handedness (Table 1)
Subsequent t-tests revealed that patients activated the superior medial frontal gyri (SMFG) less during inhibition success compared to failure, T(1,41) = 7.70, Z = 6.93, p < .001, whereas controls did not
Summary
Misophonia is a newly described psychiatric condition in which specific ordinary sounds, such as breathing or lip-smacking, provoke disproportionately strong feelings of irritability, anger, and/or disgust [1,2,3] These symptoms often cause patients to experience anticipatory negative affect and the feeling of loss of self-control, making them react aggressively to their environment or avoid situations associated with the sound(s), resulting in problems in social and/or professional domains [1, 2]. Males with high trait aggression have been found to show impaired response inhibition in a socio-emotional context, behavior that was accompanied by attenuated activation of inhibition-related brain areas [14]. Both impaired response inhibition and (trait) anger/aggression may contribute to impulsive aggression, posing the question to what extent impulsivity underlies misophonia symptoms
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