Neural bases of executive dysfunctions in parkinson?s disease: a diffusion tensor imaging study

Abstract

Event Abstract Back to Event Neural bases of executive dysfunctions in parkinson’s disease: a diffusion tensor imaging study Iwona Szatkowska1*, Ludwika Gawrys1, Artur Pilacinski2, Maciej Bielecki3, Ewa Piatkowska-Janko3, Tomasz Wolak4, Marcel Falkiewicz1, Renata Andrysiak5, Andrzej Friedman5 and Leszek Krolicki5 1 Nencki Institute of Experimental Biology, Poland 2 Hertie Institute for Clinical Brain Research, Germany 3 Warsaw University of Technology, Poland 4 Institute of Physiology and Pathology of Hearing, Poland 5 Medical University of Warsaw, Poland Diffusion tensor imaging (DTI) offers a unique opportunity to study the connectivity changes which accompany the cognitive dysfunctions in Parkinson’s disease (PD). The aim of the present study was to evaluate executive functions in non-demented patients with idiopathic PD, and to compare the fractional anisotropy (FA) values of PD patients with and without executive dysfunction. Twenty-six patients with PD participated in this study (Hoehn & Yahr' stages I and II). Patients were divided into two groups on the basis of their Wisconsin Card Sorting Test score (numbers of categories achieved). Magnetic resonance imaging was carried out with a 1.5-T scanner (GE Signa Excite). In addition to the conventional T2-weighted images, T1-weighted images and FA maps calculated from DTI were obtained. The imaging sequence for DTI was EPI-SE, TR/TE = 8300/110. Diffusion sensitization was carried out in 25 directions. The results showed significant FA reduction in the cingulate white matter in the group in which the number of categories achieved was 2. The observed connectivity changes were lateralized to the right hemisphere. This finding suggests that pathological changes in the right cingulate white matter may cause, in part, disturbances in executive functions in PD. Funding: This work was supported by a grant (NN402457138) from the Polish Ministry of Science and Higher Education. Keywords: Neuropsychiatry, Parkinson’s disease Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Neuropsychiatric Applications Citation: Szatkowska I, Gawrys L, Pilacinski A, Bielecki M, Piatkowska-Janko E, Wolak T, Falkiewicz M, Andrysiak R, Friedman A and Krolicki L (2011). Neural bases of executive dysfunctions in parkinson’s disease: a diffusion tensor imaging study. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00113 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Nov 2011; Published Online: 25 Nov 2011. * Correspondence: Dr. Iwona Szatkowska, Nencki Institute of Experimental Biology, Warsaw, Poland, i.szatkowska@nencki.gov.pl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Iwona Szatkowska Ludwika Gawrys Artur Pilacinski Maciej Bielecki Ewa Piatkowska-Janko Tomasz Wolak Marcel Falkiewicz Renata Andrysiak Andrzej Friedman Leszek Krolicki Google Iwona Szatkowska Ludwika Gawrys Artur Pilacinski Maciej Bielecki Ewa Piatkowska-Janko Tomasz Wolak Marcel Falkiewicz Renata Andrysiak Andrzej Friedman Leszek Krolicki Google Scholar Iwona Szatkowska Ludwika Gawrys Artur Pilacinski Maciej Bielecki Ewa Piatkowska-Janko Tomasz Wolak Marcel Falkiewicz Renata Andrysiak Andrzej Friedman Leszek Krolicki PubMed Iwona Szatkowska Ludwika Gawrys Artur Pilacinski Maciej Bielecki Ewa Piatkowska-Janko Tomasz Wolak Marcel Falkiewicz Renata Andrysiak Andrzej Friedman Leszek Krolicki Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.