Neural attenuation: age-related dedifferentiation in the left occipitotemporal cortex for visual word processing.

Abstract

The present study investigated the age-related neural basis of cognitive decline in the left ventral occipitotemporal cortex (vOT)-a brain area that responds selectively to visual words processing. Functional magnetic resonance imaging was used to estimate neural activity in this area, while young and old adults viewed words and line drawings. Our results demonstrated the existence of neural dedifferentiation of the left vOT in old adults during visual word processing. More specifically, this dedifferentiation was due to neural attenuation that is, decreased response to words rather than increased response to line drawings in old adults compared with young adults. In addition, individuals who showed decreased neural response to words had worse performance in visual word processing. Taken together, our findings support the neural attenuation hypothesis for the cognitive decline in visual word processing in old adults.