Neural activity for hip-knee control in those with anterior cruciate ligament reconstruction: A task-based functional connectivity analysis

Abstract

Anterior cruciate ligament injury may induce neurophysiological changes for sensorimotor control. Neuroimaging investigations have revealed unique brain activity patterns for knee movement following injury, indicating potential neural mechanisms underlying aberrant neuromuscular control that may contribute to heightened risk of secondary injury, altered movement patterns and poor patient outcomes. However, neuroimaging paradigms thus far have been limited to single joint, single motion knee tasks. Therefore, we sought to overcome prior limitations to understand the effects of injury on neural control of lower extremity movement by employing a multi-joint motor paradigm and determining differences in neural activity between ACL-reconstructed (ACLr) individuals relative to healthy matched controls. Fifteen patients with left anterior cruciate ligament reconstruction and fifteen matched healthy controls participated in this study. Neural activity was examined using functional magnetic resonance imaging during a block-designed knee-hip movement paradigm (similar to a supine heel-slide). Participants for each group were monitored and task performance was controlled via a metronome to ensure the same spatial-temporal parameters. We observed that those with ACL reconstruction displayed increased activation within the intracalcarine cortex, lingual gyrus, occipital fusiform gyrus, lateral occipital cortex, angular gyrus, and superior parietal lobule relative to controls. A follow-up task-based functional connectivity analyses using seed regions identified from the group analysis revealed connectivity among fronto-insular-temporal and sensorimotor regions within the ACLr participants. The results of this fMRI investigation suggest ACLr individuals require increased activity and connectivity in areas responsible for visual-spatial cognition and orientation, and attention for hip and knee motor control.