Abstract
Williams syndrome (WS), a rare neurodevelopmental disorder caused by a hemideletion of approximately 25 genes on chromosome 7q11.23, is behaviorally characterized by increased social drive and deficits in visuospatial construction. We previously reported that individuals with WS exhibit hypoactivation in the dorsal visual processing stream (DS) during visuospatial tasks; in contrast, we have also noted that these same DS areas are hyperactivated during processing of abstract social scenes. Here, we formally tested the hypothesis that DS activation is context-dependent by modeling a group-by-task interaction for children with WS and typically developing children (TDs) who completed both visuospatial and social tasks during fMRI.
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