Neural Actions of Digitalis

Abstract

Neural actions of digitalis drugs have been well documented but their role in the cardiovascular effects of this group of agents is a subject of considerable con­ troversy. Information concerning neural actions of these drugs, as related to their cardiovascular effects, can be grouped into the following three categories: conduction, automaticity, and refractory period; ventricular arrhythmias; and inotropic and hemodynamic effects. The first are examples where firm evidence from both animal and human studies indicates a major role for the nervous system in determining the response produced by digitalis drugs. The second is an example where impressive evidence has been obtained from some but not all animal studies indicating an important role for the nervous system in the toxic response of these agents. The third are examples where present data suggest a role for the nervous system in the well-known actions of digitalis drugs on the heart and vasculature, but more experimentation is needed to confirm present findings and to further elucidate the extent to which the nervous system partici­ pates in these responses.