Abstract
Malate and lactate dehydrogenase (MDH and LDH) are linked to a new and unusual class of proteins in mammals: proteins with an extension generated by translational readthrough and with a functional peroxisomal targeting signal in the extension. The presence of MDH and LDH in the peroxisome suggests a solution to an old question, that is how peroxisomes recycle their redox equivalents and how they transport them to the cytosol and ultimately to mitochondria.
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