Abstract
Clathrin-mediated endocytosis (CME) is an essential pathway for eukaryotic cells to internalize materials, such as nutrients and signaling proteins (1). CME occurs via the assembly of clathrin and the coordinated inward budding of the plasma membrane into transport vesicles (Fig. 1 A; (2)). During this process, what drives membrane remodeling and how and when clathrin assembles are crucial but still controversial topics that need to be addressed.
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