Abstract
BackgroundConcordance between cortical atrophy and cortical glucose hypometabolism within distributed brain networks was evaluated among cerebrospinal fluid (CSF) biomarker‐defined amyloid/tau/neurodegeneration (A/T/N) groups.MethodWe computed correlations between cortical thickness and fluorodeoxyglucose metabolism within 12 functional brain networks. Differences among A/T/N groups (biomarker normal [BN], Alzheimer's disease [AD] continuum, suspected non‐AD pathologic change [SNAP]) in network concordance and relationships to longitudinal change in cognition were assessed.ResultsNetwork‐wise markers of concordance distinguish SNAP subjects from BN subjects within the posterior multimodal and language networks. AD‐continuum subjects showed increased concordance in 9/12 networks assessed compared to BN subjects, as well as widespread atrophy and hypometabolism. Baseline network concordance was associated with longitudinal change in a composite memory variable in both SNAP and AD‐continuum subjects.ConclusionsOur novel study investigates the interrelationships between atrophy and hypometabolism across brain networks in A/T/N groups, helping disentangle the structure–function relationships that contribute to both clinical outcomes and diagnostic uncertainty in AD.
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