Abstract
Gliomas are the most frequent primary brain tumors and include a variety of different histological tumor types and malignancy grades. Recent achievements in terms of molecular and imaging fields have created an unprecedented opportunity to perform a comprehensive interdisciplinary assessment of the glioma pathophysiology, with direct implications in terms of the medical and surgical treatment strategies available for patients. The current paradigm shift considers glioma management in a comprehensive perspective that takes into account the intricate connectivity of the cerebral networks. This allowed significant improvement in the outcome of patients with lesions previously considered inoperable. The current review summarizes the current theoretical framework integrating the adult human brain plasticity and functional reorganization within a dynamic individualized treatment strategy for patients affected by diffuse low-grade gliomas. The concept of neuro-oncology as a brain network surgery has major implications in terms of the clinical management and ensuing outcomes, as indexed by the increased survival and quality of life of patients managed using such an approach.
Highlights
Frontiers in SurgeryReceived: 09 September 2016 Accepted: 16 January 2017 Published: 31 January 2017. Citation: Ghinda CD and Duffau H (2017) Network Plasticity and Intraoperative Mapping for Personalized Multimodal Management of Diffuse Low-Grade
Neurosurgical resection remains the standard of care for gliomas, and the extent of resection (EOR) is one of the most important factors affecting the patients’ survival and quality of life for both highand low-grade gliomas [1,2,3,4,5,6,7,8,9]
As depicted by the extensive work performed by several research groups, the concepts of brain connectome and brain plasticity represent promising notions that advanced the neurosurgical treatments available for neurosurgical patients affected by diffuse low-grade gliomas (DLGGs)
Summary
Received: 09 September 2016 Accepted: 16 January 2017 Published: 31 January 2017. Citation: Ghinda CD and Duffau H (2017) Network Plasticity and Intraoperative Mapping for Personalized Multimodal Management of Diffuse Low-Grade. Recent achievements in terms of molecular and imaging fields have created an unprecedented opportunity to perform a comprehensive interdisciplinary assessment of the glioma pathophysiology, with direct implications in terms of the medical and surgical treatment strategies available for patients. The current paradigm shift considers glioma management in a comprehensive perspective that takes into account the intricate connectivity of the cerebral networks. This allowed significant improvement in the outcome of patients with lesions previously considered inoperable. The current review summarizes the current theoretical framework integrating the adult human brain plasticity and functional reorganization within a dynamic individualized treatment strategy for patients affected by diffuse low-grade gliomas.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
