Abstract
We used network pharmacology to predict the correlation between the pathway of Bushenhuoxue formula in the treatment of vascular dementia and carried out experiments to verify the correlation between drug composition and disease. By screening the active components and key targets through various databases and drawing the topological network diagram, we obtained 502 effective compound targets, 601 disease targets, 95 disease-related compound targets, and 162 pathways. The pathway related to vascular dementia may be neurodegeneration-multiple diseases, PI3K-Akt signaling pathway, Mitogen-activated protein kinase signaling pathway, or HIF-1 signaling pathway. By detecting the learning and memory ability of vascular dementia rats, the morphology of the hippocampus under the electron microscope, the degree of neuronal damage, and autophagy-related proteins, the results showed that the Bushenhuoxue formula could improve the neuronal injury induced by ischemia in the hippocampus, down-regulate the level of autophagy, and thereby improve learning and memory. Therefore, the Bushenhuoxue formula may improve the ischemic injury of neurons by regulating the mechanism of neuronal autophagy.
Highlights
Dementia is a significant public health problem worldwide
The Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) contains 499 herbs and the compound ingredients of each herb registered in the 2010 edition of the Chinese Pharmacopoeia; it includes chemicals, targets, drug-target networks, and associated drugtarget-disease networks
Angelica Sinensis, Chuanxiong Rhizoma, Curcuma Aromatica Salisb, and Radix Salviae were searched in TCMSP and found (22, 2, 7, 15, and 65, respectively)
Summary
Dementia is a significant public health problem worldwide. To ensure social and economic stability, many countries have promulgated relevant policies to improve the quality of care and life of patients with dementia [1]. Vascular dementia (VD) is the most severe form of vascular cognitive impairment [2]. It refers to cognitive dysfunction’s clinical syndrome caused by cerebrovascular events based on braintissue damage [3]. It can be diagnosed by combining both clinical defects and radiographic results [4]. The molecular mechanism of the cerebrovascular disease remains unclear, and the available treatment is minimal. Some studies have even shown that VD coexists in clinical patients with Alzheimer’s disease; the combination often increases the difficulty of treatment [5]. Risk factors for VD development include hyperlipidemia, hypertension, diabetes mellitus, and tobacco use. The risk of developing VD doubles with every five years of age after 65 [7]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
