Network meta-analysis on the effect of oral care for patients with mechanical ventilation

Abstract

Objective To evaluate the clinical effect of different oral care solution. Methods Literature data were collected by computer retrieval covering China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBI) and Wanfang database, and Note Express and Addis software were used to evaluate the randomized controlled trials of literature. Results 19 separate randomized controlled trials were included in the research literature; Network Meta analysis results showed that in the prevention of ventilator-associated pneumonia, the electrolyzed oxidizing water, compound chlorhexidine, hydrogen peroxide, sodium bicarbonate, distilled water and 0.9% saline had statistically significant difference (OR=0.25, 95% CI=0.02-0.72), and the effect of sodium bicarbonate was better than the other oral care solutions; in the prevention of oral odor, the oral care solution had no significant difference (OR=0.86, 95%CI=0.34-1.74), and sodium bicarbonate of the total ranked the best preventive effect; in the prevention of oral infection, the oral care solution had no significant difference (OR=0.62, 95%CI=0.09-1.60). Conclusions Based on the meta analysis results, with 0.9% saline for common interventions, sodium bicarbonate oral nursing liquid is superior to other oral nursing liquid in the prevention of ventilator-associated pneumonia, oral smell and infection. Key words: Ventilators, mechanical; Oral care solution; Effect evaluation; Network meta-analysis