Abstract
Given the increasing health challenges posed by conditions like obesity and diabetes, a comprehensive understanding of appetite regulation and metabolic processes is crucial. Nesfatin-1 is a vital satiety factor governing hunger, satiety, and energy balance. Its role in glucose homeostasis, insulin sensitivity is well established, and cloning of this gene has enabled a wide range of applications, ranging from fundamental research elucidating appetite regulation mechanisms to translational studies aiming at innovative therapies for obesity and metabolic disorders. However, the cloning of the gene has led to a number of challenges, such as post-translational modifications and diverse splicing variants. This review aims to identify and characterize these variants to understand their specific functions and regulatory mechanisms and address challenges in nesfatin-1 cloning strategies, focusing on current splicing methods and proposing advanced techniques like single-cell RNA sequencing and CRISPR/Cas9-mediated genome editing. Collaborative efforts and technological progress, rooted in a deep nesfatin-1 understanding, are key to enhancing the quality of life for those affected, signaling a significant step towards a healthier future.
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