Abstract
Changes in the volume of an isolated innervated segment of trachea, minute volume, heart rate and blood pressure have been measured during stimulation of the medullary “respiratory centres” of anaesthetised dogs. Changes in ventilation were nearly always accompanied by changes in tracheal volume. The changes in tracheal volume were not solely the reflex effect of the changes in ventilation, since they occurred in paralysed animals artificially ventilated at fixed levels. Paralysis often reversed, but never eliminated, the tracheal response to stimulation at a particular site. Tracheal responses were highly dependent on the frequency of stimulation, high frequencies tending to lead to dilatation, low to constriction. This frequency-dependent effect was observed less commonly with the respiratory response and rarely with the cardiovascular response. There were no correlations between sites of stimulation and respiratory, tracheal or cardiovascular responses.
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