Nervous control of blood flow in the dental pulp in dogs.

Abstract

AbstractPulpal blood flow (PBF) was measured by H2‐gas clearance in 30 dogs during electrical nerve stimulation, denervation and close intraarterial infusion of noradrenaline (NA). Electrical stimulation of the cervical sympathetic nerve and NA infusion always resulted in decreased PBF. The constrictor effect was reduced by α‐blockers, but was never abolished or reversed to a vasodilation. Thus, no evidence for β‐receptors in the dental pulp blood vessels was found. The fall in PBF produced by cervical sympathetic stimulation could be prevented by cutting the inferior alveolar nerve in the mandibular canal. Stimulation of the cut inferior alveolar nerve in the mandibular canal produced variable pulpal flow changes: Both a marked increase and decrease were measured. The flow changes during inferior nerve stimulation were unaffected by α‐receptor blockade, while atropine reduced the vasoconstrictor respons or augmented the dilatory response. Electrical stimulation of the mandibular nerve before its entrance in the canal caused vasodilation, proposing a sensory antidromic axonreflex in the dental pulp. Sympathetic denervation had little or no effect on PBF, while cutting of the inferior alveolar nerve in the canal increased PBF in lower canine from 0.159 to 0.219 ml/min. g. The experiments show that pulp blood vessels of the dog may be controlled by both vasodilator and vasoconstrictor nerve fibers.