Abstract
Dental implantation has been the primary method for the treatment of tooth loss, but longer than 3 months healing times are generally required. Because immediate load implants are suitable only for certain categories of implant patients, it has value to develop a novel method to facilitate the implant-bone osseointegration process. Cylindrical titanium implants were implanted in the tooth sockets of beagles, and microelectrode stimulation of the sympathetic nerves in the infraorbital nerve was performed after implantation for 1 week. The authors found that one-sided nerve stimulation was shown to evoke consistent electric potential changes in both sides of the infraorbital nerves. Moreover, after 4 weeks of implantation, more new bone was clearly observed around the implants in the beagles that received electrical stimulation treatment than was observed in the control animals. Furthermore, a higher mineralization density was measured in the new peri-implant bone tissues of the stimulated beagles when compared to controls. These results demonstrate that the simple and safe physical method of microelectrode stimulation to sympathetic nerves can promote the formation of new bone and the osseointegration of implants. This technique is worth promoting and has the potential to reduce the healing time of dental implantation in future clinical cases.
Highlights
Tooth loss leads to problems with chewing, pronunciation, appearance, and mental health
To investigate the influence of microelectrode stimulation on bone healing with titanium implants, sixteen cylindrical titanium implants were implanted into each socket of an extracted maxillary anterior tooth in eight female adult beagles
The heart rate (HR) and oxygen saturation (SpO2) of beagles with implants remained normal during the microelectrode stimulation of the sympathetic nerves of the infraorbital nerve
Summary
Tooth loss leads to problems with chewing, pronunciation, appearance, and mental health. A method of immediate implants and immediate loading was developed to solve the problem of delayed restoration It is only suitable for certain categories of implant patients, and there are a number of clinical cases in which immediate loading cannot be performed without a serious risk of failure. Www.nature.com/scientificreports authors wanted to develop an approach to accelerate the processes of new bone formation and osseointegration to reduce the time interval between dental implantation and crown restoration. Many researchers have successfully regulated the bone formation process by using drugs or by transecting the sympathetic nerve of the bone, though the mechanisms of action for these methods of regulation are not clearly understood[16,17,18]. The authors believe that our simple and safe method of microelectrode stimulation holds great promise to accelerate the implant-bone osseointegration process in clinical cases
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