Abstract
ObjectivePrevious studies suggest that the presence of diabetic peripheral polyneuropathy (DPN) is associated with atherosclerotic diseases; however, little is known about the relationship between diabetic nerve conduction velocity (NCV) versus arterial stiffness and atherosclerosis parameters.MethodsThe subjects in this study were 292 men with type 2 diabetes mellitus (T2DM). All subjects underwent NCV examination at median and tibial nerves as motor nerve (MCV) as well as median and sural nerves as sensory nerve (SCV). Brachial-ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT) were evaluated as arterial stiffness and atherosclerosis parameters.ResultsPearson’s correlation coefficient showed that NCV at all sites negatively correlated with baPWV, maximal and mean IMT (IMT-Max and IMT-Mean), and plaque score (all p values p<0.01 at least). Multiple regression analyses adjusted for confounding factors such as age, duration of diabetes, body mass index, HbA1c, fasting C-peptide, systolic blood pressure, HDL-cholesterol, LDL-cholesterol and albuminuria showed that the association of NCV with IMT-Max, ITM-Mean, and plaque score remained significant (all p values p<0.05 at least) except that between SCV at median and IMT-Max. Moreover, SCV at median (forearm) and sural were significantly associated with baPWV (p = 0.023 and p = 0.027, respectively).ConclusionThe present study showed that DPN estimated by quantitative NCV is linearly associated with the deterioration of arterial stiffness and atherosclerosis parameters in T2DM independently of various diabetic and atherosclerotic factors.
Highlights
Type 2 diabetes mellitus (T2DM) is known to be a crucial risk factor for cardiovascular disease (CVD)
Multiple regression analyses adjusted for confounding factors such as age, duration of diabetes, body mass index, HbA1c, fasting C-peptide, systolic blood pressure, HDL-cholesterol, LDL-cholesterol and albuminuria showed that the association of Nerve conduction velocity (NCV) with intima-media thickness (IMT)-Max, ITM-Mean, and plaque score remained significant except that between SCV at median and IMT was represented as maximum (IMT-Max)
The present study showed that Diabetic peripheral polyneuropathy (DPN) estimated by quantitative NCV is linearly associated with the deterioration of arterial stiffness and atherosclerosis parameters in T2DM independently of various diabetic and atherosclerotic factors
Summary
Type 2 diabetes mellitus (T2DM) is known to be a crucial risk factor for cardiovascular disease (CVD). Previous largescale interventional studies have shown that intensive glycemic control could not completely decrease the risk of CVD events and mortality in patients with T2DM [5,6,7]. They are urgent tasks to clarify factors associated with CVD events and to define the management strategy for patients with T2DM. Previous studies suggest that the diabetic microvascular complications have relationship with cardiovascular event and death. Cardiovascular event and mortality risks rise with presence of retinopathy, nephropathy and cardiac autonomic neuropathy among diabetes complications. To investigate the relationship between NCV and parameters of atherosclerosis, we conducted a cross-sectional study in patients with T2DM
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