Abstract
Abstract Experimental renal disease was produced in 5 Taiwan monkeys (Macaca cyclopsis) by the intravenous injection of anti-monkey-kidney serum obtained from rabbits. All developed proteinuria and statistically significant hypoproteinemia. Four monkeys revealed statistically significant reduction of the albumin fraction. Two monkeys had generalised edema, and 3 showed statistically significant hypercholesterolemia. These clinical abnormalities were associated with histopathologic renal lesions which closely simulated those of the nephrotic syndrome as observed in children. In 7 other monkeys receiving rabbit anti-monkey-kidney serum, the disease appeared to be intensified by the administration of ACTH or prednisolone before or during heteronephrotoxic serum injections. Obvious generalized edema associated with ascites and hydrothorax was observed in all animals. In addition to the foregoing changes, statistically significant increase in values of non-protein nitrogen and urea nitrogen in the blood was observed in 6 of the 7 monkeys. Evident gross hematuria was noted in 2 young monkeys. Significantly increased serum α 2 -globulin fraction was observed in 4 monkeys. More prominent hypercholesterolemia was noted in 5. Attempts to produce experimental renal disease by the intravenous injection of anti-monkey-kidney serum obtained from ducks failed in Taiwan monkeys, and ACTH and prednisolone had no significant effect on the clinical and histologic response.
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