Abstract
The present study investigated the nephrotoxic effect of aqueous extract of Dialium guineense stem bark in normal Wistar albino rats. Thirty-five male rats were used. Graded doses of the extract ranging from 200 to 5000 mg/kg body weight, bwt, were administered to the test rats daily for twenty-eight days. The control rats received distilled water. Thereafter plasma levels of creatinine, urea, electrolytes and urease activity were determined. There were no significant differences in the concentrations of the measured renal parameters, when compared with control group (p > 0.05). These results appear to suggest that the extract may be safe at concentrations not exceeding 5000 mg/kg bwt. However, further studies spanning several months may be necessary.
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