Abstract
We read with amazement and astonishment, the recent report by House et al .1 in the Journal of the American Medical Association (JAMA) suggesting that water-soluble B-vitamin supplementation with folic acid (2.5 mg/day), vitamin B(6) (25 mg/day) and vitamin B(12) (1 mg/day), versus matching placebo, accelerated diabetic nephropathy. Interestingly, it took the authors, recruiting from five different medical centers, as many as 6 long years to recruit only 238 participants, raising concerns about consistency of follow-up of the various participants scattered out among the five recruiting centers. Second, it is unclear whether a particular center contributed a preponderance of the participants thereby raising concerns about a single-center effect.2 Such details are now preferred to be available in reports of parallel-group randomized …
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