Nephrotic syndrome with rapidly progressive renal failure (RPRF) in light chain myeloma

J Janya,H Karunatilake,A Jayanaga,D Serasinghe,A Kirubaharan,H Jayawardhana

doi:10.4038/jrcs.v26i1.115

Abstract

No abstract available

Highlights

Nephrotic syndrome, defined by proteinuria with bland sediments, hypoalbuminaemia and oedema is not a known cause of RPRF as opposed to crescentic glomerulonephritides
Monoclonal gammopathies are characterized by a proliferation of a single clone of plasma cells which produce immunologically similar gamma globulin called M proteins
70% of Monoclonal immunoglobulin deposition disease (MIDD) is light chain deposition disease (LCDD). 2.LCDD typically presents with hy

Summary

Introduction

Nephrotic syndrome, defined by proteinuria with bland sediments, hypoalbuminaemia and oedema is not a known cause of RPRF as opposed to crescentic glomerulonephritides. We present a 44-year-old previously healthy woman with arapidly progressive non-oliguric renal failure and nephrotic range proteinuria with bland sediments.There was no bleeding tendency, evidence of recurrent infections, chronic back or joint pain, acrocyanosis, skin rashes, oral ulcers, history ofnephrotoxic drug use, recurrent pyelonephritis or urolithiasis. She was found to have a normochromic normocytic anaemia with moderate rouleaux formation, arapid erythrocytic sedimentation rate and a pseudohyponatremia suggestive of an underlying para-proteinemia.

Discussion

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Conclusion