Abstract
This review aimed to summarize the current recommendations for conversion treatment of children with nephrotic syndrome and to identify the specifics of therapeutic management in Ukraine.
 The KDIGO guidelines of 2021 and the IPNA recommendations of 2020 and 2023, previous experience in Ukraine, and relevant clinical and legal aspects in 2022 were analyzed. Differences in the definitions of nephrotic children adopted in recent years were noted. International practice on disease conversion at the onset of nephrotic syndrome in children, steroid dependence, frequent recurrent course, and steroid resistance was summarized, and current measures of renal protection in children were presented. The spectrum of medicine used to treat nephrotic syndrome (glucocorticosteroids, calcineurin inhibitors, cyclophosphamide, mycophenolate mofetil, levamisole, chlorambucil, rituximab), their priority, dosage, monitoring, and duration of treatment in pediatrics depending on disease characteristics were presented. The consistency between the national treatment protocol and international recommendations for the main groups of medicines available in Ukraine was noted. In addition, the focus and limitations of treatment interventions depending on glucocorticosteroid sensitivity in Ukraine under martial law were summarized and practical points to facilitate clinical decision-making were highlighted. The urgency of establishing an adaptive guideline for the treatment of nephrotic children based on international experience and Ukrainian capabilities depending on the challenges of martial law was confirmed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.