Abstract
Background Cisplatin (Cis) is an anticancer drug; however, it has dose-dependent renal toxicity. The current study aims to investigate the protective effects of Zataria multiflora Boiss. hydroalcoholic extract (Z.M.B), carvacrol, and thymol on cisplatin-induced nephrotoxicity in rats. Materials and Methods Forty-two Wistar male rats were randomly allocated into six groups (n = 7). Group I received normal saline; group II received Cis (7 mg/kg. ip); group III received the Z.M.B extract only (500 mg/kg/d, po); group IV received Z.M.B extract (500 mg/kg/d, po) + Cis; group V received carvacrol (50 mg/kg/d, po) + Cis; and group VI received thymol (50 mg/kg/d, po) + Cis. The levels of biochemical markers, oxidative stress parameters, and histopathological staining were determined in serum and renal tissues. Also, the chemical compositions (carvacrol and thymol) of the Z.M.B extract were assayed by HPLC analysis. Result The results revealed that Z.M.B extract, carvacrol, and thymol markedly decreased the renal index as compared with the Cis-only group. Also, carvacrol and thymol significantly reduced the blood urea nitrogen level as compared with the Cis-only group. Furthermore, Z.M.B extract, carvacrol, and thymol significantly attenuated the Cis-induced increase in malondialdehyde and nitric oxide metabolite. Additionally, histopathological examination showed that Z.M.B extract, carvacrol, and thymol markedly ameliorated Cis-induced renal tubular necrosis. Conclusion The results showed renoprotective effects of Z.M.B extract, carvacrol, and thymol in Cis-induced nephrotoxicity in rats. Therefore, Z.M.B extract can be considered as a potential candidate for the protection of nephrotoxicity induced by Cis.
Highlights
Cisplatin (Cis) as the short form of cis-diaminedichloroplatinum is one of the major effective drugs used in chemotherapy for a variety of cancers including testicular, ovarian, and cervical cancers [1]
Conclusion. e results showed renoprotective effects of Z.M.B extract, carvacrol, and thymol in Cis-induced nephrotoxicity in rats. erefore, Z.M.B extract can be considered as a potential candidate for the protection of nephrotoxicity induced by Cis
A number of cases of acute renal failure in hospitalized patients are due to the unavoidable prescription of Cis [2], and despite the hydration therapy as a way to reduce renal toxicity, about one-third of patients who received Cis would experience irreversible kidney injuries [3]. e free Cis in the blood is filtered by glomeruli and enters the tubular cell through a transfer process. e main route for the transfer of Cis is active in renal transfer cells; some amount of Cis enters through the process of simple release, the kidney collects more Cis than any other organ and is the main route for its excretion [4]
Summary
Cisplatin (Cis) is an anticancer drug; it has dose-dependent renal toxicity. e current study aims to investigate the protective effects of Zataria multiflora Boiss. hydroalcoholic extract (Z.M.B), carvacrol, and thymol on cisplatininduced nephrotoxicity in rats. Hydroalcoholic extract (Z.M.B), carvacrol, and thymol on cisplatininduced nephrotoxicity in rats. Forty-two Wistar male rats were randomly allocated into six groups (n 7). E results revealed that Z.M.B extract, carvacrol, and thymol markedly decreased the renal index as compared with the Cis-only group. Carvacrol and thymol significantly reduced the blood urea nitrogen level as compared with the Cis-only group. Z.M.B extract, carvacrol, and thymol significantly attenuated the Cis-induced increase in malondialdehyde and nitric oxide metabolite. Histopathological examination showed that Z.M.B extract, carvacrol, and thymol markedly ameliorated Cis-induced renal tubular necrosis. E results showed renoprotective effects of Z.M.B extract, carvacrol, and thymol in Cis-induced nephrotoxicity in rats. Erefore, Z.M.B extract can be considered as a potential candidate for the protection of nephrotoxicity induced by Cis Conclusion. e results showed renoprotective effects of Z.M.B extract, carvacrol, and thymol in Cis-induced nephrotoxicity in rats. erefore, Z.M.B extract can be considered as a potential candidate for the protection of nephrotoxicity induced by Cis
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