Nephroprotective acitvity of Amomum subulatum seeds against cypermethrin induced nephrotoxicity in rats

Abstract

The objective of the present study was to evaluate nephroprotective activity of Amomum subulatum seed extract against Cypermethrin induced nephrotoxicity in albino rats. The animals were divided into five different groups consisting of six rats each. Except normal control and test drug alone group, all the rats were treated with Cypermethrin 25g/kg body weight orally for 28 consecutive days and test group IV & V (ASSE 200 & 400mg/kg body weight) were co administered with Cypermethrin orally for 28 consecutive days. On the 28th haematalogical, biochemical and histopathalogical parameters were estimated. The chronic administration of Cypermethrin caused significant elevation in the serum creatinine and urea level and increased lipid peroxidation in the kidney tissue homogenate as compared to normal control. The histological examination of kidney tissues revealed mild fatty changes especially in the sub capsular region in sections, dilatation of glomerulus along with obliteration of periglomerular space and shrinkage of glomerulus was observed. The co administration of test drug significantly attenuated the Cypermethrin induced elevated serum urea and creatinine and lipid peroxidation in tissue homogenate. Thus we can conclude the Amomum subulatum seed extract has significant nephroprotective effect and reversed Cypermethrin induced nephrotoxicity.