Abstract
The effect of streptozotocin-induced diabetes, in the rat, on the excretion of nephrogenous cyclic AMP was investigated. This excretion was significantly less than that observed in control animals (P < 0.001). Administration of insulin partly restored the excretion of nephrogenous cyclic AMP to control values. In view of the reported elevated parathyroid hormone levels in the diabetic rat, the present findings suggest target organ resistance to parathyroid hormone in this diabetic animal model.
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Schedule a callMore From: Biochemical and biophysical research communications
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