Abstract
The aim of this study was to evaluate the analgesic efficacy of two different intraarticular injections; morphine and/or neostigmine. Sixty patients scheduled for arthroscopic knee surgery under general anesthesia were randomly allocated into four groups at the end of the surgery to receive morphine 2 mg (Group M), neostigmine 500 μg (Group N), morphine 2 mg and neostigmine 500 μg (Group MN) and 20 mL saline (Group S) intraarticularly. Visual analog scale (VAS) scores, analgesic consumption and side effects through 24 hours were recorded postoperatively. VAS scores were lower in the first three groups, while total analgesic consumption was significantly lower in Group M (p< 0.05). Side effects did not differ between the groups.Although intraarticular neostigmine provided pain control and diminished analgesic use compared to placebo, the combination of neostigmine and morphine did not result in a comparable postoperative pain score and analgesic use with morphine alone.
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