Abstract
The BALB 3T3 clone A31-1-1 mouse embryo fibroblast cell line at passage 7–13 was used for studying neoplastic transformation with a mutagen isolated from beef extract and identified as 2-amino-3 methylimidazo [4,5- d] quinoline (IQ). IQ at a concentration of 1, 5 and 15 ng/ml induced transformed type III foci. No foci were detected in control plates treated with DMSO alone. At the highest concentration of IQ (30 ng/ml) no transformed type III foci were observed and plating efficiency was reduced. The results demonstrate a positive transforming capability of this compound on mammalian cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
