Abstract
Neoplastic pigment cells can be induced by N-methyl-N-nitrosourea (MNU) in certain genotypes of the fish Xiphophorus that never develop such cells spontaneously. In some, the neoplastic cells retain their incompletely differentiated stage and proliferate, apparently due to unrestrained division, into malignant pigment cell neoplasms (‘melanomata’). In other fish most of the neoplastic pigment cells become terminally differentiated and form harmless ‘hyperplastic foci’. Terminal differentiation of MNU-induced neoplastic pigment cells appears to be predominantly controlled by a gene complex designated ‘differentiation’ (Diff).
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