Abstract
An antigens of tuberculosis mycobacteria (MTB), microgranulomas with acid-fast grains, cell wall deficient (CWD) MTB were found in tumors of small domestic animals. CWD MTB were isolated from tumor in all cases. The isolates did not differ in morphology and antigenic composition, either from each other or from isolates from human tumor cell cultures (Kasumi, Jurkat, Hela), had up to 26 common antigens with typical MTB, were resistant to antibiotics affecting cell wall synthesis. MTB as universal intracellular pathogen with unique filterability and «immortality» can be considered as the most likely etiological agent of oncogenesis based on the hypothesis following: DNA absorption of aging and necrotic normal cells by persistent microorganisms, hybridization of their DNA with host DNA with subsequent expression of the hybrid genome turns normal cells into cancer ones.
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