Abstract
The chemosensitivity enhancive mechanism on nitric oxide includes three routes: adjust the expression level of hypoxia-inducible factor-1α (HIF-1α), classical nitric oxide signal pathway and combine with the reaction products of other molecules. Traditional nitric oxide donor compounds include nitroferricyanide, organic nitrates, s-nitrosothiols, azo onium diol aldoxide, non-steroids anti-inflammatory drugs, whose function of antitumor and chemotherapy sensitization caused extensive attention. Key words: Nitric oxide donors; Neoplasms; Chemosensitizer
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