Abstract
IntroductionIntraductal papillary mucinous neoplasm (IPMN) of pancreas can progress from low grade dysplasia to high grade dysplasia and invasive carcinoma. Methodsin this single center retrospective series we analyze the clinicopathological features and long-term follow up of patients who underwent pancreatic resection for IPMN, from January 2009 to December 2019. Results31 patients were diagnosed with IPMN. Nine males and 22 females. The mean age was 67 years. Twenty-seven patients (87%) were symptomatic. Seven patients had main duct IPMN, 11 branch type IPMN and 13 mixed type IPMN. High-risk stigmata were found in 20 patients (64.5%) and worrisome features in 10 patients (32.2%). Thirteen patients (41.9%) had an associated invasive carcinoma, 4 (12.9%) high-grade dysplasia and 14 (45.2%) low-grade dysplasia. The follow-up was from 2 to 12 years. Median survival for patients with IPMN and associated invasive carcinoma was 45.8 months and disease-free survival was 40.8 months. ConclusionsIPMN had higher prevalence in females, mostly symptomatic and high incidence of associated invasive carcinoma with branch type. The 5-year survival was good even with associated invasive carcinoma.
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