Abstract

Abstract Neopeapyran ( 1 ), an unusual furo[2,3 b ]pyran analogue, together with a new cyclopeptide, turnagainolide C ( 2 ), were isolated from Streptomyces sp. S2236 associated with the rhizosphere soil of Panax notoginseng . The planar structure and relative configuration of neopeapyran ( 1 ) were elucidated on the basis of spectroscopic techniques, while the absolute configuration was determined by TDDFT calculation. The absolute configuration of turnagainolide C ( 2 ) was determined by partial hydrolysis, together with the advanced Marfey's method and spectroscopic analysis. The antimicrobial activities of these two compounds were also investigated.

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