Abstract
The current standard screening for retinopathy of prematurity (ROP), indirect ophthalmoscopy (IO), is widely considered to induce physiologic stress in infants.1-3 This study aims to characterize the stress associated with ROP examination by assessing changes in vital signs during standard examination and XyCAM, a new noninvasive retinal imager that utilizes laser speckle contrast imaging (LSCI) to capture information on ocular blood flow dynamics without directly contacting the eye. We tested the hypothesis that LSCI examination will cause less physiologic stress to the infants as indicated by more stable heart rate, respiratory rate, and oxygen saturation.
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