Abstract
Summary 1. The erythrocyte T 3 uptake method of Hamolsky has been modified so that it is adaptable to individuals in the pediatric age range. 2. Using this technique, we have shown elevated erythrocyte T 3 values in the fullterm neonate. These fall to within the adult range when the infant is 6 to 9 weeks of age. The elevation of erythrocyte T 3 uptake appears more marked and more prolonged in the premature infant. 3. The elevated erythrocyte T 3 uptakeshows that the increased protein-bound iodine or butanol extractable iodine of the neonate is not the result of an increased thyroid-binding protein. The different relationships of the T 3 uptake to the BEI in the maternal and in the cord blood specimens indicate that the observations in the newborn are not merely a reflection of maternal thyroid status. Our data suggest that there is a true increase in thyroid secretion in the newborn infant.
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