Abstract

BackgroundNeonatal tetanus (NT) is still considered as one of the major causes of neonatal death in many developing countries. The aim of the present study was to assess the characteristics of sixty-seven infants with the diagnosis of neonatal tetanus followed-up in the Pediatric Infectious Diseases Ward of Dicle University Hospital, Diyarbakir, between 1991 and 2006, and to draw attention to factors that may contribute (or may have contributed) to the elimination of the disease in Diyarbakir.MethodsThe data of sixty-seven infants whose epidemiological and clinical findings were compatible with neonatal tetanus were reviewed. Patients were stratified into two groups according to whether they survived or not to assess the effect of certain factors in the prognosis. Factors having a contribution to the higher rate of tetanus among newborn infants were discussed.ResultsA total of 55 cases of NT had been hospitalized between 1991 and 1996 whereas only 12 patients admitted in the last decade. All of the infants had been delivered at home by untrained traditional birth attendants (TBA), and none of the mothers had been immunized with tetanus toxoid during her pregnancy. Twenty-eight (41.8%) of the infants died during their follow-up. Lower birth weight, younger age at onset of symptoms and at the time admission, the presence of opisthotonus, risus sardonicus and were associated with a higher mortality rate.ConclusionAlthough the number of neonatal tetanus cases admitted to our clinic in recent years is lower than in the last decade efforts including appropriate health education of the masses, ensurement of access to antenatal sevices and increasing the rate of tetanus immunization among mothers still should be made in our region to achieve the goal of neonatal tetanus elimination.

Highlights

  • Neonatal tetanus (NT) is still considered as one of the major causes of neonatal death in many developing countries

  • Neonatal tetanus (NT), a preventable disease, remains one of the major causes of neonatal death in many developing countries [1,2,3]. It is an acute disease characterized by generalized rigidity and convulsive spasms of skeletal muscles, and is caused by an exotoxin of the bacterium Clostridium tetani which is a gram-positive and anaerobic rod forming spores that are very resistant to heat and the usual antiseptics [4]

  • In their article published in European Journal of Epidemiology in 1999, our colleques had reported a total of 55 cases of NT to have been hospitalized in the Pediatric Infectious Diseases Ward of our hospital between 1991 and 1996 [10]

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Summary

Introduction

Neonatal tetanus (NT) is still considered as one of the major causes of neonatal death in many developing countries. Neonatal tetanus (NT), a preventable disease, remains one of the major causes of neonatal death in many developing countries [1,2,3]. It is an acute disease characterized by generalized rigidity and convulsive spasms of skeletal muscles, and is caused by an exotoxin of the bacterium Clostridium tetani which is a gram-positive and anaerobic rod forming spores that are very resistant to heat and the usual antiseptics [4].

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