Abstract
The influence of neonatal treatment with androgens or estrogens in rats was evaluated by measuring in the testes and the brain of adult animals the conversion of 4-androstene-3, 17-dione, 3β-hydroxy-5-androstene-17-one, 3β-hydroxy-5-pregnen-20-one, and testosterone. In the testes, neonatal treatment with estradiol benzoate produced an enzymatic defficiency manifested by decreased utilization of C-21 precursor and 17-oxo reduction. Neonatal treatment with testosterone propionate produced an increase in 17β-hydroxyoxidase activity and decrease in the activity of 17-oxo reductase. In addition, the amounts of testoster-one and androstenedione in the brain of treated rats were significantly decreased suggesting an alteration in the permeability of the blood-brain barrier.
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