Abstract
Neonatal sepsis is an important but underestimated problem around the world. It is defined as disease affecting newborns ≤ 1 month of age with clinical symptoms and positive blood cultures. Infection is an important cause of morbidity and mortality during the neonatal period, despite the great improvements in intensive neonatal care and the use of extended spectrum antimicrobial agents. The incidence of this disease in developed countries is 1/1,000 in normal term neonates and 4/1,000 in preterm neonates. These values increase in low-weight preterm neonates [1]. In developing countries, this incidence increases to 2.2-8.6/1,000 live births [2]. Neonatal sepsis can be subdivided into early-onset neonatal sepsis and late-onset neonatal sepsis.
Highlights
Neonatal sepsis is an important but underestimated problem around the world
In the case of early neonatal sepsis caused by bacteria, these microorganisms could arise from a prematurely ruptured amniotic membrane which becomes infected generally affecting the amniotic fluid or preterm delivery in a mother colonized by such bacteria and who may have a much higher risk of infecting their offspring due to the immaturity of their immune system [6,7]
Stoll et al [10] found that 44% and 10.7% of EONS were caused by E. coli and SGB, respectively
Summary
Neonatal sepsis is an important but underestimated problem around the world It is defined as disease affecting newborns ≤ 1 month of age with clinical symptoms and positive blood cultures. Infection is an important cause of morbidity and mortality during the neonatal period, despite the great improvements in intensive neonatal care and the use of extended spectrum antimicrobial agents. The incidence of this disease in developed countries is 1/1,000 in normal term neonates and 4/1,000 in preterm neonates. These values increase in low-weight preterm neonates [1]. Neonatal sepsis can be subdivided into early-onset neonatal sepsis and late-onset neonatal sepsis
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