Neonatal risk factors in cerebral palsy

Abstract

Cerebral palsy (CP) is a movement disorder caused by damage to the developing brain. It affects patient self-help, creates family problems, and increases care costs. CP has many risk factors, although the trigger is often unclear, resulting in treatment delays and permanent complications. To improve monitoring and early diagnosis, a study to establish total risk factors for predicting cerebral palsy in the neonate is a useful study especially for patients in small hospitals who do not have specialized doctors. A case-control study of CP risk factors in neonate, born at Thammasat University Hospital, Thailand from 2005 to 2014. Using multivariable logistic regression, neonatal and maternal characteristics, as well as prenatal, perinatal and postnatal risks, were compared in normal children (control) and patients diagnosed with CP (case). These risks and evidence of difference ( P -value) are in Table 1 and Table 2 ; CP independent risk is in Table 3 . Cerebral and non-cerebral malformation, small for gestational age, preterm, multifetal gestation, neonatal jaundice, and non-congenital infections of neonatal infants were risks, with odds ratio (OR) = 313.03, 16.45, 5.67, 8.45,11.39, 10.99 and 147.87, respectively. Cerebral and non-cerebral malformation, small for gestational age, preterm, multifetal gestation, neonatal jaundice, and non-congenital infections of the neonatal infants were predictive risks. However, low Apgar score, uterine and cord anomalies, neonatal seizure, neonatal encephalopathy, congenital infections, and ventilator use remain questionable with low incidence. Multicenter research to enhance data scope would be useful.