Neonatal respiratory inhibition causes repeated severe hypoxemia

Abstract

Objective The goal of this study was to verify the details of neonatal respiratory inhibition (NRI) in healthy infants. Methods We screened for NRI in 521 infants who weighed at least 2000 g and who were born at a gestational age of at least 36 weeks. Respiratory inhibition was defined as severe hypoxemia, accompanied by clinical manifestations of central cyanosis and a decrease in SpO2 to less than 70%. NRI consists of feeding hypoxemia, respiratory inhibition after crying (RIAC), and respiratory inhibition after gastroesophageal reflux (RIGER). The subjects were monitored continuously via pulse oximetry from birth until discharge. To identify the details of NRI, we analyzed detailed notes taken by both parents and medical staff during monitoring using specific software designed to interpret pulse oximetry measurements. The mothers of infants with feeding hypoxemia received nursing guidance. Results NRI was observed in 268 (51.4%) infants (feeding hypoxemia in 227 (43.6%); RIAC in 121 (23.2%); and RIGER in 12 (2.3%)). Among perinatal factors, NRI was related to diabetes mellitus (p = .008; odds ratio = 3.290; 95% CI: 1.371–7.895), twin pregnancy (p = .032; odds ratio = 2.061; 95% CI: 1.062–3.998), and cesarean section (p = .036; odds ratio = 1.537; 95% CI: 1.027–2.299) using multiple logistic regression analysis. Almost all infants with RIAC and RIGER, even those with severe cases, recovered until discharge. However, 93 (41.0%) infants with feeding hypoxemia needed additional feeding control after being discharged. Despite the provision of nursing guidance in feeding control, 143 (63.0%) infants experienced feeding hypoxemia continuously. The more frequently the infants experienced feeding hypoxemia, the more severe the degree of feeding hypoxemia became. Breastfeeding reduced the frequency and degree of feeding hypoxemia compared to bottle-feeding. Conclusions NRI was often observed in healthy infants. Breastfeeding and careful feeding control should be recommended to mothers of infants with repeated feeding hypoxemia.