Abstract
This paper reports measuring contractility of neonatal rat ventricular myocytes (NRVM) using a novel cell force sensor, namely, a double-sided micropillar array (DMA) developed for both single cell force measurements using conventional microscopy as well as high-throughput cell force mapping based on the optical moire effect. The contraction force map of NRVM cultured on DMA was acquired with nanonewton and submicron scale resolution using confocal microscopy. For the moire-based method, the local average of the cell contraction force was derived from the moire pattern, which allows mapping cell contraction force using a 20X objective lens, enabling the acquisition of a larger field-of-view than conventional microscopy.
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