Abstract
In resume, intracrinology refers to in situ synthesis of active steroids in the cell where the steroids have their action (1). Four criteria are necessary to extend intracrinology to the developing lung in context of BPD. First, there must be circulating SSPs in the fetal circulation. Second, the lung cell must be able to transform these into androgens in situ. Third, these lung cells must be androgen receptors positive to allow an androgen dependent reaction. Lastly, the androgen action must be part of the lung physiology.
Highlights
IntracrinologyIntracrinology refers to the production of active sex steroids in situ within the cells where the action takes place
In 2004, we proposed that androgens should play a positive role in lung development for both sexes [38]
In order to better understand the action of steroids in the developing lung and demystify the dimorphism associated with the prevalence of BPD in males, a gender-sex-based analysis approach, which takes into account sex, was chosen
Summary
Intracrinology refers to the production of active sex steroids in situ within the cells where the action takes place. It has been shown that after removing androgens of testicular origin, the prostate still produces dihydrotestosterone (DHT) from an inactive circulating sex steroid precursor of adrenal origin. Can this concept of intracrinology be extended to the developing lung?. More than four decades ago, Farrell and Avery [9] reported a higher incidence of RDS in male vs female This sexual dimorphism has been considered to be caused by the presence of androgens in the male lung that cause a delay in the PTII cell maturation and a delay in the surge of surfactant lipid production. BPD was originally described as a heterogeneous group of lung disorders associated with preterm birth and lung impairment due to mechanical ventilation [13]
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