Abstract
Leukemoid reaction is defined as an absolute neutrophil count(ANC) of >30,000/cumm. First described by Holland and Maurer in 1963 leukemoid reaction is associated with infection, anemia, bronchopulmonary dysplasia, use of antenatal steroids, prematurity. Neonatal leukemoid reaction is seen as a neonatal response to hypoxia and can mimic leukemia. In our case the baby was premature and the leukemoid reaction was due to early onset sepsis. Clinicians need to keep sepsis in mind while dealing with neonatal leukemoid reaction.J Nepal Paediatr Soc 2016;36(3):298-299
Highlights
Theleukemoid reaction during neonatal period is defined as ANC of >30,000/cumm during first week of life[1]
The first cases of neonatal leukemoid reaction were described by Holland and Maurer in 1963 and were associated with infection, anemia, bronchopulmonary dysplasia, use of antenatal Steroids, prematurity, chromosomal abnormalities[2]
Neonatal sepsis can present with Hyperleucocytosis(total leucocyte count >100,000/mm3and needs to be distinguished from leukemia and other myeloproliferative disorders[3,4]
Summary
Theleukemoid reaction during neonatal period is defined as ANC of >30,000/cumm during first week of life[1]. Neonatal Leukemoid Reaction - A diagnostic dilemma. The first cases of neonatal leukemoid reaction were described by Holland and Maurer in 1963 and were associated with infection, anemia, bronchopulmonary dysplasia, use of antenatal Steroids, prematurity, chromosomal abnormalities[2]. It is seen as a neonatal response to hypoxia and can mimic leukemia.
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