Abstract
Congenital Parvovirus B19 infection is a rare but serious condition that can result in hydrops fetalis and fetal death. Due to the virus’ cytotoxic effect on fetal red blood cell precursors, postnatal infection can cause a neonatal viremia and secondary pure red cell aplasia. Here, we describe a case of congenital parvovirus infection in a preterm infant complicated by hydrops fetalis and chronic anemia that responded to postnatal treatment with intravenous immunoglobulin (IVIG) administered on day of life 44. After treatment, the anemia resolved as the neonate exhibited interval increases in hemoglobin, hematocrit, and reticulocyte count with no subsequent need for red blood cell transfusions.
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