Abstract
The association of inflammatory, autoimmune and coagulation factors with cerebral palsy (CP) was examined at the National Institutes of Health, Bethesda, MD, and the Immunochemistry Laboratory, George Washington University Medical Center, using dried, preserved neonatal blood spot specimens of 31 children enrolled in the California Birth Defects case-controlled study of spastic CP and compared to 65 control children.
Highlights
The association of inflammatory, autoimmune and coagulation factors with cerebral palsy (CP) was examined at the National Institutes of Health, Bethesda, MD, and the Immunochemistry Laboratory, George Washington University Medical Center, using dried, preserved neonatal blood spot specimens of 31 children enrolled in the California Birth Defects case-controlled study of spastic CP and compared to 65 control children
Concentrations of interleukins 1, 8, 9, tumor necrosis factor-x, and RANTES were elevated in the neonatal blood specimens of children with CP
Higher concentrations of antibodies to antiphospholipid, antithrombin III, factor V Leiden mutation, and to proteins C and S were found in the blood analytes of CP children compared to controls
Summary
The association of inflammatory, autoimmune and coagulation factors with cerebral palsy (CP) was examined at the National Institutes of Health, Bethesda, MD, and the Immunochemistry Laboratory, George Washington University Medical Center, using dried, preserved neonatal blood spot specimens of 31 children enrolled in the California Birth Defects case-controlled study of spastic CP and compared to 65 control children. Concentrations of interleukins 1, 8, 9, tumor necrosis factor-x, and RANTES were elevated in the neonatal blood specimens of children with CP. Higher concentrations of antibodies to antiphospholipid, antithrombin III, factor V Leiden mutation, and to proteins C and S were found in the blood analytes of CP children compared to controls.
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